How to Restart a Run in The Binding of Isaac: Antibirth
Best Answer
If you're playing on a controller, pause the game, then hold down the 'RT' trigger and press 'Start' to restart.
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You can restart a run by simply exiting to the main menu and starting a new game from there.
Super easy! Just press 'R' on your keyboard to restart a run in Antibirth.
Just die. Seriously, it's the quickest way to restart your run.
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